Wuhan Yuancheng Gongchuang Technology Co., Ltd.

CAS: 148-01-6, Mequindox, Feed Addtives manufacturer / supplier in China, offering High Quality Mequindox CAS: 148-01-6 of Veterinary Medicine, Adrenalone Hydrochloride, Dl-Adrenalin, Epinephrine Bitartrate, Isoprenaline Hydrochloride, 99% Purity Estradiol with Safe Shipping and so on.

Supplier Homepage Product List Feed Additives High Quality Mequindox CAS: 148-01-6 of Veterinary Medicine

High Quality Mequindox CAS: 148-01-6 of Veterinary Medicine

FOB Price:US $1.2 - 1.5 / Piece
Min. Order (Pieces) FOB Price
10+ US $1.2-1.5 / Piece
Get Latest Price
Min. Order: 10 Pieces
Production Capacity: 500000
Transport Package: as Required
Payment Terms: T/T, Western Union, Money Gram, Bitcpin

Basic Info.

Model NO.:CAS: 148-01-6
Type:Feed Processing and Preservation Agent
Mf:C32h36clno8
Storage Temp.:0-6°c
Usage:Antibacterial
Main Ingredient:Ferrous Fumarate
Shape:Powder Feed
Main Nutrients:Functional Feed
Trademark:YC
Specification:25kg/bags
Origin:China
HS Code:2901220000

Product Description

High  Quality Mequindox CAS: 148-01-6 of Veterinary Medicine 

There is an old saying in China: there are thousands of miles to meet, I believe that the next person i meet is you. Wish us a pleasant cooperation.Any need please feel free contact me.I am waiting for you coming.
 
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 Quick Detail:
 
Product NameMequindox
CAS NO148-01-6
AppearanceWhite powder
25KG/barrel,10kg/barrel25KG/barrel,10kg/barrel
MW598.08
MFC32H36ClNO8
EINECS200-035-3
SynonymsSEROPHENE;PERGOTIME;CLOMPHID;CLOMID;CLOMIFENECITRATE;CLOMIPHENE CITRATE;CLOMIPHENE CITRATE SALT;-[4-(2-CHLORO-1,2-DIPHENYLETHENYL)
Place of originChina
Package1kg/aluminium foil bag or as required
ShippingEMS , DHL , TNT , FedEx , UPS
Delivery timewithin 24 hours upon receipt of payment.
UseUsed as a feed additive



 Product Description:

1.Mequindox, a quinoxaline-N-dioxide derivative that possesses antibacterial properties, has been widely used as a feed additive in the stockbreeding industry in China. While recent pharmacological studies have uncovered potential hazardous effects of mequindox, exactly how mequindox induces pathological changes and the cellular responses associated with its consumption remain largely unexplored. In this study, we investigated the cellular responses associated with mequindox treatment.

2.We report here that mequindox inhibits cell proliferation by arresting cells at the G2/M phase of the cell cycle. Interestingly, this mequindox-associated deleterious effect on cell proliferation was observed in human, pig as well as chicken cells, suggesting that mequindox acts on evolutionarily conserved target(s). To further understand the mequindox-host interaction and the mechanism underlying mequindox-induced cell cycle arrest, we measured the cellular content of DNA damage, which is known to perturb cell proliferation and compromise cell survival.

3.Accordingly, using γ-H2AX as a surrogate marker for DNA damage, we found that mequindox treatment induced cellular DNA damage, which paralleled the chemical-induced elevation of reactive oxygen species (ROS) levels. Importantly, expression of the antioxidant enzyme catalase partially alleviated these mequindox-associated effects. Taken together, our results suggest that mequindox cytotoxicity is attributable, in part, to its role as a potent inducer of DNA damage via ROS.




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There is an old saying in China: there are thousands of miles to meet, I believe that the next person i meet is you. Wish us a pleasant cooperation.Any need please feel free contact me.I am waiting for you coming.
 
 
whtasapp;8618202779784
 
 
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