99% Tetracaine Hydrochloride/Tetracaine HCl CAS: 136-47-0 Local Anesthesia
English Name:Tetracaine hydrochloride
Synonyms:(Dimethylamino) ethyl ester hydrochloride; 4- (butylamino) -Benzoic acid, 2- (dimethylamino) ethyl ester, monohydrochloride; p- Butylalobenzoyl-2-dimethylaminoethanol hydrochloride; Amethocaine hydrochloride; Anethaine; Butethanol; Curtacain; Decicain; Gingicain M; Menonasal; Pantocaine; Pontocaine hydrochloride; Tetracaine hydrochloride; Tonexol; Tetracaine ¡¤ HCL
Appearance: White crystalline powder
Procaine hydrochloride is a local anesthetic, can temporarily block the conduction of nerve fibers and anesthetic effect, the role of strong, low toxicity, and no addiction, but the skin, mucosal penetration is weak, not suitable for the surface Anesthesia, clinically mainly used for infiltration, spinal and conduction anesthesia.
At room temperature white fine needle crystal or crystalline powder, odorless, taste bitter and linen, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Hydrochloride in the structure of procaine hydrochloride can be hydrolyzed to produce p-aminobenzoic acid and diethylamino ethanol. Under certain conditions, p-aminobenzoic acid can be further decarboxylated to produce toxic aniline.
Prasaine hydrochloride structure with aromatic primary amino, easy to oxidative discoloration, pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution of this product is stable between pH 3.0 and 5.0. Therefore, the preparation of procaine hydrochloride injection, the general need to add acid pH3.3 ~ 5.5 between, and strictly control the sterilization temperature and time to 100 ¡æ circulation steam sterilization 30min is appropriate, and should pay attention to shading, save.
The structure of the aromatic amino group in dilute hydrochloric acid, and sodium nitrite to produce diazonium salt, alkaline ¦Â-naphthol coupling reaction, resulting in scarlet azo compounds.
CLINICAL PHARMACOLOGY:Tetracaine Hydrochloride Ophthalmic Solution, USP 0.5% acts by decreasing the permeability of the neuronal membrane, thereby decreasing the flux of sodium, potassium and other ions associated with propagation of the nerve impulse. The onset of anesthesia usually begins within 30 seconds and lasts a relatively short period of time.
INDICATIONS AND USAGE:For procedures in which a rapid and short acting topical ophthalmic anesthetic is indicated such as in tonometry, gonioscopy, removal of corneal foreign bodies, conjunctival scraping for diagnostic purposes, suture removal from the cornea or conjunctiva, other short corneal and conjunctival procedures.
Should not be used by the patient without physician supervision, or in those persons showing hypersensitivity to any component of this preparation.
For topical ophthalmic use only. Not for parenteral use. Not for injection. Do not use solution if it contains crystals or if it is cloudy or discolored. Prolonged use results in diminished duration of anesthesia and retarded healing. This may cause the drug to be used more frequently, creating a "vicious circle". Subsequent corneal infection and/or corneal opacification with accompanying permanent visual loss or corneal perforation may occur. Prolonged use may also produce severe keratitis.
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