99% Purity Highest Quality Pharmaceutical Grade Procaine HCl Procaine Hydrochloride
99% Purity Pharmaceutical Grade Procaine Hydrochloride CAS 51-05-8
|Product Name:||Procaine hydrochloride|
|Product Categories:||Pharmaceutical;Sodium channel;APIS;Anesthetics;Pharmaceutical intermediate|
|Procaine hydrochloride Chemical Properties|
|storage temp.||room temp|
|Stability:||Stable. Incompatible with strong oxidizing agents.|
|CAS DataBase Reference||51-05-8(CAS DataBase Reference)|
|EPA Substance Registry System||Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, monohydrochloride(51-05-8)|
|RIDADR||UN 2811 6.1/PG 3|
|Local anesthetic||Procaine hydrochloride is a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia. |
White fine needle crystal or crystalline powder at room temperature, no smell, taste slightly bitter and Ma, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Procaine hydrochloride ester bond structure can be hydrolyzed to produce amino acid and diethylaminoethanol, under certain conditions, the amino acid may be further decarboxylated toxic aniline.
The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0 ~ 5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ºC steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.
The product structure of aromatic primary amino group in dilute hydrochloric acid can generate diazonium salt with sodium nitrite, coupling reaction occurs when add alkaline β- naphthol, generating azo compounds scarlet.
The above information is edited by the chemicalbook of Kui Xiongfeng.
|Chemical Properties||white crystalline powder|
|Usage||Local anesthesic;Na+ channel blocker|
|Usage||Procaine is a local anesthetic of the amino ester group that is primarily used as a topical anesthetic. Procaine is also used to control the pain of intramuscular injection of penicillin as well as in dentistry.|
|Usage||Non Caine local anesthetic.|
Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.
Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.
Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. About one in 3000 people have an atypical form of pseudocholinesterase, which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.
A white, crystalline powder
A white, crystalline powder
comply with the requirement
APPEARANCE OF SOLUTION
|Clear and coulorless||Confirms|
Comply with 2,6-dimethylaniline
Confirms with P2005 standard
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