Wuhan Yuancheng Gongchuang Technology Co., Ltd.

Mycophenolate Mofetil, Mmf, Pharmaceutical Raw Materials manufacturer / supplier in China, offering Highest Quality 99% Mycophenolate Mofetil CAS: 115007-34-6, Adrenalone Hydrochloride, Dl-Adrenalin, Epinephrine Bitartrate, Isoprenaline Hydrochloride, 99% Purity Estradiol with Safe Shipping and so on.

Supplier Homepage Product List Pharmaceutical Intermediates Highest Quality 99% Mycophenolate Mofetil CAS: 115007-34-6

Highest Quality 99% Mycophenolate Mofetil CAS: 115007-34-6

FOB Price:US $445 / kg
Min. Order (kg) FOB Price
1+ US $445 / kg
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Min. Order: 1 kg
Production Capacity: 5000kg/Month
Transport Package: 1kg/Aluminum Foil Bag, 25kg/Drum
Payment Terms: L/C, T/T, D/P, Western Union, Money Gram

Basic Info.

Model NO.:CAS: 115007-34-6
Powder:Yes
Customized:Non-Customized
Suitable for:Adult
State:Solid
Purity:99%
Product Name:Mycophenolate Mofetil
Synonyms:Mmf
CAS No:115007-34-6
Mf:C23h31no7
MW:433.49
Appearance:White Powder
Uses:Pharmaceutical Intermediate
Delivery:Enough Storage Guarantee Fast Delivery
Shipping out:in 24 Hours After Confirm Payment
Shipping Method:EMS, DHL, TNT, FedEx, UPS, Hongkong EMS
Trademark:WHYCG
Specification:ISO 9001 2008
Origin:China
HS Code:2942000000

Product Description

Highest Quality 99% Mycophenolate mofetil CAS: 115007-34-6

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Product Name:Mycophenolate mofetil
Synonyms:AKOS 92025;4-HEXENOIC ACID,6-(1,3-DIHYDRO-4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-ISOBENZOFURANYL)-4-METHYL-,2-(4-MORPHOLINYL)ETHYL ESTER;MMF;2-Morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methyl-hex-4-enoate;Mycophenolate mofetil;Mycophenolate Mofetil(MMF);Matimaikaofenzhi;4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (E)-
CAS:115007-34-6
MF:C23H31NO7
MW:433.49
EINECS:12879-494-5
Product Categories:API;Anti-cancer & immunity
Mol File:115007-34-6.mol
 
 
Mycophenolate mofetil Chemical Properties
CAS DataBase Reference115007-34-6(CAS DataBase Reference)
General descriptionMycophenolate mofetil (MMF), whose trade name is "Cellcept", was developed by the American Syntex Company. It is the semisynthetic derivative of mycophenocli acid (MPA) which is separated out from the glycolysis product of mold Penicillin glaucum. Mycophenolate mofetil is reusable cytostatics who have a history of clinical application being more than 10 years. It is mainly used for the treatment of psoriasis. At late 1980s, animal experiments have confirmed that it can significantly prolong the survival time of the allogeneic transplanted organs such as kidney, heart and islet of rodents. Sollinger et al has successfully applied MMF to the treatment of anti-rejection reaction upon kidney transplant for the first time with a remarkable effect. FDA has approved officially for its registration in 1995 under the trade name "Cellcept", making clinical applications been added into a new and effective immunosuppressant for prevention and treatment of rejection reaction.
ApplicationIt is mainly used for prevention the allograft rejection reaction upon organ transplant as mostly seen in renal transplant and also suitable in the heat, liver transplant especially for the refractory rejection reaction after the transplant. It can be combined together with cyclosporine and corticosteroids. It can also be applied to rheumatoid arthritis, systemic lupus erythematosus, primary glomerulonephritis, psoriasis and some other autoimmune diseases. Apply oral administration in kidney transplant; initial dose: 2 ~ 3mg/kg per day, maintenance dose: 1 ~ 2mg/ kg per day and take in 2 to 3 times. The dose can be adjusted according to specific condition. Rheumatoid arthritis: 300 mg daily.
Clinical application1. Organ Transplantation
Organ transplantation is transplanting the healthy organ of donor into another body for the rapid recovery of that function. The greatest threat of organ transplantation is the rejection reaction, mainly being presented as acute rejection reaction. Although currently there are relative mature protocols of immunosuppression such as the combined therapy of cyclosporine A, azathioprine, tacrolimus, cyclophosphamide, prednisone, and methylprednisolone, but there are still many cases that a considerable number of patients has got transplant rejection which ultimately lead to chronic rejection and transplant failure. In addition, adverse effects of immunosuppressive drugs also further restrict their clinical application. In 1995, people had successfully applied mycophenolate mofetil for organ transplant surgery to prevent and treat graft rejection. On May of the same year, FDA approved the application of mycophenolate mofetil in renal transplantation treatment. In 1996, it had been successfully applied for the first time in kidney transplant patients. Following researchers have found that mycophenolate mofetil in combination with cyclosporine and prednisone can reduce the incidence of acute rejection reaction after kidney transplantation, and also has good efficacy on refractory renal transplant rejection. Mycophenolate mofetil alone can be used as a kind of immunosuppressants for long-term maintenance therapy which can improve renal function and of special benefit for accepting elderly donors with relatively poor renal function. 
2. Immune kidney disease
Immune kidney disease is a group of chronic glomerulus disease caused by variety triggering factors of same immune pathological characteristics. Immunological renal diseases includes anaphylactic purpura nephritis, refractory nephrotic syndrome, primary nephrotic syndrome, lupus nephritis, IgA nephropathy, etc., because of the dysfunction of patient's immune system, the resulting immune complex is deposited in the kidney which cause damage to the inherent cells of the kidney and cause inflammation reactions. This disrupts the normal function of kidney inherent cells, causing symptoms such as proteinuria, hematuria, and edema of the patients.
3. Digestive autoimmune diseases
(1) Autoimmune liver diseases Autoimmune liver diseases (ALD) is an autoimmune response mediated chronic liver disease. 20% of the ALD patients are not sensitive to the hormoneand azathioprine without appropriate treatment for long-term. Studies have shown that researchers believe that for ALD patients on whom traditional methods treatment has no effect, 88% of patients can alleviate the symptoms with applying mycophenolate mofetil. The application of mycophenolate mofetil can significantly reduce the amount of hormones.
(2) Autoimmune pancreatitis Autoimmune pancreatitis (AIP) is a pancreas inflammation lesion caused by the immune response triggered by the CD4+ adjuvant cells' recognition to the antigen which is the own part of pancreas itself. Mycophenolate mofetil is used in patients of autoimmune pancreatitis mediated by hormone-dependent IgG4 and IgG4 mediated cholangitis. The related patient initially got symptoms alleviated by taking prednisone for 40mg/d. However, when the hormone concentration is reduced to 10mg/d, jaundice, hyperbilirubinemia, and elevated transaminase activities occurred. The patients were not able to tolerate the adverse reactions of adding azathioprine. Subsequent application of 750 mg mycophenolate mofetil for 2 times/d, being combined with 15 mg prednisone caused adverse reactions such as high blood sugar and other hormone-related adverse reactions after 3 months, thus gradually disabled prednisone and increase the dose of mycophenolate mofetil to the amount of 1g/times and 2 times/d. After 4 months, both the energy metabolism as well as blood sugar level of patients got alleviation without seeing any adverse reactions. Application of mycophenolate mofetil solves the problem that patients can't use hormones. This demonstrates that mycophenolate mofetil or other immunosuppressants can be used to maintain or alleviate autoimmune pancreatitis.
4. Other diseases
(1) Refractory idiopathic thrombocytopenic purpura (ITP) is a common autoimmune bleeding disorder with a complicated pathogenesis and great difficulty of treatment. Traditional treatment usually adopt corticosteroids which although be effective on the majority of patients, however, still leaving some patients with poor results, called refractory idiopathic thrombocytopenic purpura (R-ITP). Mycophenolate mofetil as a new immunosuppressant with fewer adverse reactions, and is an effective approach of R-ITP therapy which has broad clinical application.
(2) Psoriasis is characterized by occurrence of varying sizes of papules skin, erythema with surface being covered with silvery white scales and also clear boundary on the surface of the skin. It mainly occurs in the scalp, extensor limbs and back. The etiology is not yet clear. In recent years, most scholars believed that it is related to heredity, infection, metabolic disorders, immune dysfunction, endocrine disorders and the environment. Studies have shown that there are no celar differences of safety and efficacy between methotrexate and Mycophenolate mofetil in the treatment of psoriasis, but mycophenolate mofetil has better security. Patients who can't tolerate the side effects of methotrexate or with contraindications can choose mycophenolate mofetil.
(3) Myasthenia gravis (MG) is a chronic autoimmune disease caused by the dysfunction of conduction function between nerve conduction and neuromuscular. Immunosuppressant is important on the treatment of MG with its major mechanism of action of inhibiting the formation of auto-antibodies and reducing the related damage of cholinergic receptors or associated receptors in order to protect the smooth flow of neural excitation pathways, thereby improving the patient's muscle weakness. Compared with other immunosuppressant, mycophenolate mofetil has fewer side effects.
Adverse reactionsMainly include hypertension, atrial fibrillation, orthostatic hypotension, tachycardia, thrombosis, vasodilatation, headache, dizziness, insomnia, anxiety, high cholesterol, blood sugar changes, potassium and calcium metabolism disorders, acidosis, increased alkaline phosphatase, increased creatinine, hyperlipidemia, parathyroid dysfunction, nausea, vomiting, indigestion, and liver function abnormalities. Bone marrow suppression is commonly seen. Disable it upon severe neutropenia. The incidences of fungal dermatitis, skin rashes, Amblyopia and cataract are about 3% to 10%.
Precautions1. Contraindications: People who are allergic to this drug or mycophenolic acid (MPA); pregnant women and lactating women should be disabled.
2. Take with caution: Patients of severe active digestive diseases, bone marrow suppression, being accompanied by hypoxanthine-guanine phosphoribosyltransferase ribose kinase deficiency, severe heart, and liver dysfunction.

COMPETITIVE ADVANTAGE:
1. Rich experience.
Having been specialized in this field for years, we have rich experience and widespread sales network around the word. Our steroids and hormones have been exported to overseas, like Europe, Africa, Asia, America and other countries. We are not got good feedback from our guest, but also established long business relationship with them.
 
2. Great quality and high purity
Good quality is one secret for our success. All of our products enjoys high purity. Thus, it can make sure our client's need. Welcome order the samples, MOQ just 10 grams.
 
3. Safest and fastest delivery.
We have mass stock, so that we can arrange the delivery within 24hours once receiving the payment. Tracking number would be informed quickly after shipment.
We have our own way of packing which could ship 0.01 kilo to 50 kilo products a time.
 
4. Good after-sales service.
24/7 is available. We will tell you the package updated info ASAP. And try our best to solve various problems customers encountered!
 
5. Experiential shopping
Besides raw steroid powder and liquid, we offer hormone solution and formula. We can teach you how to make hormone solution on the site. Any visit to our lab is welcomed.

 
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