Tetracaine CAS: 94-24-6 Mucosal Surface Anesthesia Raw Powders
Synonyms:2- (Dimethylamino) ethyl 4- (butylamino) benzoate; 2- (Dimethylamino) ethyl p- (butylamino) benzoate; 2-Dimethylaminoethylester kyseliny p-butylaminobenzoove; 2-dimethylaminoethylesterkyselinyp-butylaminobenzoove; ) -benzoicaci2- (dimethylamino) ethylester; amethocaine; Anetain
Appearance: White crystalline powder
Procaine hydrochloride is a local anesthetic, can temporarily block the conduction of nerve fibers and anesthetic effect, the role of strong, low toxicity, and no addiction, but the skin, mucosal penetration is weak, not suitable for the surface Anesthesia, clinically mainly used for infiltration, spinal and conduction anesthesia.
At room temperature white fine needle crystal or crystalline powder, odorless, taste bitter and linen, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Hydrochloride in the structure of procaine hydrochloride can be hydrolyzed to produce p-aminobenzoic acid and diethylamino ethanol. Under certain conditions, p-aminobenzoic acid can be further decarboxylated to produce toxic aniline.
Prasaine hydrochloride structure with aromatic primary amino, easy to oxidative discoloration, pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution of this product is stable between pH 3.0 and 5.0. Therefore, the preparation of procaine hydrochloride injection, the general need to add acid pH3.3 ~ 5.5 between, and strictly control the sterilization temperature and time to 100 ¡æ circulation steam sterilization 30min is appropriate, and should pay attention to shading, save.
The structure of the aromatic amino group in dilute hydrochloric acid, and sodium nitrite to produce diazonium salt, alkaline ¦Â-naphthol coupling reaction, resulting in scarlet azo compounds.
Epidural block: commonly used concentration of 0.15 ~ 0.3% solution, combined with lidocaine hydrochloride, the maximum concentration of 0.3%, a commonly used amount of 40 ~ 50mg, the amount of 80mg.
Subarachnoid block: commonly used mixture (1% tetracaine hydrochloride 1ml and 10% glucose injection 1ml, 3% ephedrine hydrochloride 1ml mixed use), a common amount of 10mg, 15mg is limited, 20mg for the pole the amount.
Nerve conduction block: commonly used concentration of 0.1% to 0.2%, a commonly used amount of 40 ~ 50mg, the amount of 100 mg.
Mucosal surface anesthesia: commonly used concentration of 1%, ophthalmology with 1% isotonic solution, ENT with 1 ~ 2% solution, a limit of 40 mg.·
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