High Purity Nicotinamide (Vitamin B3)
Product Name: Nicotinamide
Synonyms: Pyridine-3-carboxamide; Niacinamide cell culture tested; Nicotinamide (1.06818); Niacinamide; Vitamin PP; VPP; Pyridine-3-Carboxyamide; 3-Pyridinecarboxyamide; Vitamin B3; Nicotinic acid amide; Nicotinic Amide
CAS No.: 98-92-0
EINECS No.: 202-713-4
Molecular Formula: C6H6N2O
Molecular Weight: 122.12
Melting point: 128-131º C
Boiling point: 150-160 ° C
Flashing point: 182 ° C
Water Solubillity: 1000 g/L (20 º C)
Appearance: White crystaline powder
Application: The prevention and treatment of pellagra
Nicotinamide, (ni-k-t-n-md) also known as niacinamide and nicotinic amide, is the amide of nicotinic acid (vitamin B3 / niacin). Nicotinamide is a water-soluble vitamin and is part of the vitamin B group. Nicotinic acid, also known as niacin, is converted to nicotinamide in vivo, and, though the two are identical in their vitamin functions, nicotinamide does not have the same pharmacological and toxic effects of niacin, which occur incidental to niacin's conversion. Thus nicotinamide does not reduce cholesterol or cause flushing, although nicotinamide may be toxic to the liver at doses exceeding 3 g/day for adults. In cells, niacin is incorporated into nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), although the pathways for nicotinic acid amide and nicotinic acid are very similar. NAD+ and NADP+ are coenzymes in a wide variety of enzymatic oxidation-reduction reactions. It's produced by the aqueous aminolysis of 3-cyanopyridine (nicotinonitrile) and subsequent crystallization.
Nicotinamide has demonstrated anti-inflammatory actions that may be of benefit to patients with inflammatory skin conditions. These conditions include acne vulgaris, and the compound can suppress antigen-induced, lymphocytic transformation and inhibit 3', 5'-cyclic-AMP phosphodiesterase. Nicotinamide has demonstrated the ability to block the inflammatory actions of iodides known to precipitate or exacerbate inflammatory acne.
NicAzel and Nicomide are the names of oral acne medications that include nicotinamide as their most predominant ingredient, based on this area of research. Nicotinamide is also found as part of a new adjunct supplement combination called, AzerizinTM. According to the makers of Azerizin, this adjunct is part of their prescription dietary supplement product, which they claim helps manage inflammatory skin conditions. Nicotinamide is also used topically as a 4% or 5% gel or cream - as effective as topical 1% clindamycin (8-week double-blind trial) performed at the New York University College of Medicine. Unlike topical Erythromycin or Clindamycin it does not precipitate bacterial resistance in treating inflammatory acne. Nicotinamide acne treatment is also available as Nicotinamide pads and cream.
Nicotinamide is also reported to be an effective skin whitener in topical application.
|Characteristics||White crystalline powder||Pass|
|Heavy metals||≤ 0.001||< 0.001|
|Related substances||Complies with the standard||pass|
|Sulphated ash||≤ 0.02||< 0.02|
|Melting point||234~240° C||236.2~237.3° C|
|Loss on drying||< 1.0||0.40|