Procaine Hydrochloride/Procaine HCl /CAS 51-05-8 Acts on Peripheral Nerve
English Name:Procaine hydrochloride
Synonyms:Aminocaine; anadolor; anestil; atoxicocaine; Benzoicacid, 4-amino-, 2- (diethylamino) ethylester, monohydrochloride; benzoicacid, p-amino-, 2- (diethylamino) ethylester, monohydrochloride; bernocaine
Appearance: White crystalline powder
Procaine hydrochloride is a local anesthetic, can temporarily block the conduction of nerve fibers and anesthetic effect, the role of strong, low toxicity, and no addiction, but the skin, mucosal penetration is weak, not suitable for the surface Anesthesia, clinically mainly used for infiltration, spinal and conduction anesthesia.
At room temperature white fine needle crystal or crystalline powder, odorless, taste bitter and linen, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Hydrochloride in the structure of procaine hydrochloride can be hydrolyzed to produce p-aminobenzoic acid and diethylamino ethanol. Under certain conditions, p-aminobenzoic acid can be further decarboxylated to produce toxic aniline.
Prasaine hydrochloride structure with aromatic primary amino, easy to oxidative discoloration, pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution of this product is stable between pH 3.0 and 5.0. Therefore, the preparation of procaine hydrochloride injection, the general need to add acid pH3.3 ~ 5.5 between, and strictly control the sterilization temperature and time to 100 ¡æ circulation steam sterilization 30min is appropriate, and should pay attention to shading, save.
The structure of the aromatic amino group in dilute hydrochloric acid, and sodium nitrite to produce diazonium salt, alkaline ¦Â-naphthol coupling reaction, resulting in scarlet azo compounds.
1. Mainly used for infiltration anesthesia.
2. For the lower abdomen takes a long time surgery. Can also be used for local anesthesia of the limbs.
3. For "closed therapy", the treatment of certain injuries and inflammation, can damage, inflammation of the symptoms of some relief.
4. To correct limb vasomotor dysfunction.
5. treatment of neurosis
For infiltration anesthesia, the solution concentration of 0.25% to 0.5%, each dosage 0.05 ~ 0.25g, not more than 1.5g per hour. Used as spinal anesthesia, 1 times the amount should not exceed 0.15g, with 5% solution. Local anesthesia for limbs, 0.5% solution 40 ~ 150ml. Nerve conduction block with 1% to 2% solution, 1 times no more than 1g.
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